Is Naproxen (Aleve) Safe During Pregnancy?

Answer
Naproxen (Aleve) is generally advised to be avoided during pregnancy, especially from 20 weeks onward, due to potential risks to the unborn baby's kidneys and amniotic fluid levels. For pain relief, acetaminophen (Tylenol) is often recommended as a preferred alternative throughout pregnancy.
Is Naproxen (Aleve) Pregnancy-Safe?
Our verdict for Naproxen (Aleve) during pregnancy is: AVOID.
The U.S. Food and Drug Administration (FDA) advises avoiding NSAIDs, including naproxen, from 20 weeks of pregnancy onward unless specifically recommended by a doctor 2.
Why is Naproxen (Aleve) advised to be avoided in later pregnancy?
Taking NSAIDs, such as naproxen, around 20 weeks or later in pregnancy can cause rare but serious kidney problems in the unborn baby 1. This can lead to low levels of amniotic fluid, a condition known as oligohydramnios 1. This specific warning is distinct from earlier, longstanding third-trimester NSAID warnings concerning the premature closure of the fetal ductus arteriosus 1.
What about Naproxen use in early pregnancy?
NIH MotherToBaby fact sheets note that naproxen has not been shown to cause major birth defects when used briefly in the first half of pregnancy 3.
What are the general recommendations for pain relief during pregnancy?
- The FDA recommends avoiding NSAIDs, including naproxen, at 20 weeks or later unless a doctor specifically recommends it 2.
- Acetaminophen (Tylenol) remains the preferred over-the-counter pain reliever throughout pregnancy, according to ACOG 3.
Remember, SafeMom provides informational content and is not a substitute for professional medical advice. Always consult with your healthcare provider for personalized guidance during pregnancy.
Related ingredients
Acetaminophen
Acetaminophen (Tylenol) is the first-line OTC pain reliever and fever reducer in pregnancy per ACOG. Considered safe at recommended doses across all…
Ibuprofen
Avoid ibuprofen after 20 weeks of pregnancy. NSAIDs can cause fetal kidney problems, oligohydramnios, and (after 30 weeks) premature closure of the…
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Sources
- (2020). FDA Drug Safety Communication: NSAID use in pregnancy. U.S. Food and Drug Administration. View source →
- (2020). FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later. FDA Drug Safety Podcast. View source →
- (2023). Naproxen (Aleve) fact sheet. NIH MotherToBaby. View source →