Common question Short answer: yes

Is Naproxen (Aleve) Safe During Pregnancy?

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Answer

Naproxen (Aleve) is generally advised to be avoided during pregnancy, especially from 20 weeks onward, due to potential risks to the unborn baby's kidneys and amniotic fluid levels. For pain relief, acetaminophen (Tylenol) is often recommended as a preferred alternative throughout pregnancy.

Reviewed by Jamie G, Founder & Researcher · Last reviewed September 11, 2026 · 3 sources cited · 1 min read

Is Naproxen (Aleve) Pregnancy-Safe?

Our verdict for Naproxen (Aleve) during pregnancy is: AVOID.

The U.S. Food and Drug Administration (FDA) advises avoiding NSAIDs, including naproxen, from 20 weeks of pregnancy onward unless specifically recommended by a doctor 2.

Why is Naproxen (Aleve) advised to be avoided in later pregnancy?

Taking NSAIDs, such as naproxen, around 20 weeks or later in pregnancy can cause rare but serious kidney problems in the unborn baby 1. This can lead to low levels of amniotic fluid, a condition known as oligohydramnios 1. This specific warning is distinct from earlier, longstanding third-trimester NSAID warnings concerning the premature closure of the fetal ductus arteriosus 1.

What about Naproxen use in early pregnancy?

NIH MotherToBaby fact sheets note that naproxen has not been shown to cause major birth defects when used briefly in the first half of pregnancy 3.

What are the general recommendations for pain relief during pregnancy?

  • The FDA recommends avoiding NSAIDs, including naproxen, at 20 weeks or later unless a doctor specifically recommends it 2.
  • Acetaminophen (Tylenol) remains the preferred over-the-counter pain reliever throughout pregnancy, according to ACOG 3.

Remember, SafeMom provides informational content and is not a substitute for professional medical advice. Always consult with your healthcare provider for personalized guidance during pregnancy.

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Sources

  1. (2020). FDA Drug Safety Communication: NSAID use in pregnancy. U.S. Food and Drug Administration. View source →
  2. (2020). FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later. FDA Drug Safety Podcast. View source →
  3. (2023). Naproxen (Aleve) fact sheet. NIH MotherToBaby. View source →

Jamie G

Founder & Researcher, SafeMom

Jamie founded SafeMom after researching the ingredient-regulations gap that leaves expecting parents without a single trustworthy answer source. Not a medical professional — all medical questions should be directed to your OB or midwife.

Reviewed September 11, 2026 3 sources cited Editorial standards Suggest a correction

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