Acetaminophen

Active · CAS 103-90-2

Safe

Acetaminophen (Tylenol) is the first-line OTC pain reliever and fever reducer in pregnancy per ACOG. Considered safe at recommended doses across all…

Adapalene

Active · CAS 106685-40-9

Avoid

Avoid adapalene (Differin) during pregnancy. Although it’s a newer, third-generation retinoid with limited human pregnancy data, the class-wide retinoid teratogenicity caution applies.…

Aloe Vera

Other · CAS 85507-69-3

Safe

Topical aloe vera is pregnancy-safe with a long traditional and modern usage record. Soothing for sunburn, pregnancy itch, dry skin. NOTE: oral…

Avobenzone

Uv filter · CAS 70356-09-1

Caution

Use avobenzone cautiously in pregnancy. The FDA Maximal Usage Trial confirmed it reaches plasma concentrations above the safety threshold after a single…

Azelaic Acid

Active · CAS 123-99-9

Safe

Azelaic acid is FDA Pregnancy Category B — the strongest evidence base among topical acne and brightening actives. Effective for acne, rosacea,…

Bakuchiol

Active · CAS 10309-37-2

Safe

Bakuchiol is the leading pregnancy-safe alternative to retinol. A 2018 head-to-head clinical trial showed bakuchiol matched retinol's improvements in fine lines and…

Benzoyl Peroxide

Active · CAS 94-36-0

Caution

Benzoyl peroxide is generally considered safe in pregnancy at low topical concentrations (under 5%, applied to small areas). Systemic absorption is around…

Calcium Carbonate (Tums)

Active · CAS 471-34-1

Safe

Calcium carbonate (Tums) is the first-line antacid in pregnancy and is considered safe at recommended doses. It neutralizes stomach acid for fast…

Ceramides

Emollient · CAS 100403-19-8

Safe

Ceramides are fully pregnancy-safe. They are lipid molecules identical to those naturally in your skin's barrier — restoring rather than altering native…

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