Diphenhydramine (Benadryl) is pregnancy-safe with a long use history across all trimesters. First-generation antihistamine — causes drowsiness, which is useful for sleep…

Avoid DMDM hydantoin in pregnancy. It’s a formaldehyde-releasing preservative that slowly emits formaldehyde over the product’s shelf life — exposure source is…

Avoid formaldehyde during pregnancy. IARC Group 1 human carcinogen. Inhalation and dermal exposure are linked to increased miscarriage risk in salon-worker studies…

Use products listing 'fragrance' or 'parfum' cautiously during pregnancy. The term can hide phthalates, allergens, and endocrine disruptors under U.S. trade-secret rules.…

Glycerin is fully pregnancy-safe. Long pregnancy-use safety record across cosmetics, OTC drugs, and food. Works by drawing water from the dermis and…

Hyaluronic acid is fully pregnancy-safe at any cosmetic concentration. It's a large polymer molecule naturally present in skin — too large to…

Avoid hydroquinone during pregnancy. Up to 35–45% systemic absorption — the highest of any topical cosmetic ingredient. Pregnancy data are limited, so…

Avoid ibuprofen after 20 weeks of pregnancy. NSAIDs can cause fetal kidney problems, oligohydramnios, and (after 30 weeks) premature closure of the…

Absolutely avoid isotretinoin (Accutane) in pregnancy. It is one of the most potent known human teratogens — first-trimester exposure causes a roughly…