Loratadine

Active · CAS 79794-75-5

Safe

Loratadine (Claritin) is the preferred non-sedating second-generation antihistamine for pregnancy allergies. Multi-decade safety record with no consistent evidence of teratogenicity. Considered safe…

Niacinamide

Active · CAS 98-92-0

Caution

Niacinamide (vitamin B3) is generally considered pregnancy-safe in topical skincare. The 'caution' rating reflects limited data on high systemic doses, not topical…

Octinoxate

Uv filter · CAS 5466-77-3

Avoid

Avoid octinoxate during pregnancy. The most-used chemical UVB filter globally, with estrogenic endocrine-disruptor signals in animal and cell studies. Flagged alongside oxybenzone…

Octocrylene

Uv filter · CAS 6197-30-4

Caution

Use octocrylene cautiously during pregnancy. It degrades to benzophenone (a potential carcinogen) over time — particularly in older or heat-exposed sunscreens. Systemic…

Oxybenzone

Uv filter · CAS 131-57-7

Avoid

Avoid oxybenzone during pregnancy. Endocrine disruptor that crosses the placenta. Studies link higher maternal urinary oxybenzone to altered birth weight and Hirschsprung…

Parabens

Preservative · CAS 99-76-3

Caution

Use parabens cautiously in pregnancy. They have weak estrogenic activity, and some cohort studies link prenatal exposure to altered birth weight and…

Phenoxyethanol

Preservative · CAS 122-99-6

Safe

Phenoxyethanol is pregnancy-safe at cosmetic concentrations (up to 1% in finished products). The FDA, EU SCCS, and Health Canada all accept it…

Phthalates

Plasticizer · CAS 117-81-7

Avoid

Avoid phthalates during pregnancy. This family of endocrine-disrupting plasticizers is associated with altered male reproductive development (reduced anogenital distance) and neurodevelopmental effects…

Pseudoephedrine

Active · CAS 90-82-4

Avoid

Avoid pseudoephedrine (Sudafed) in the first trimester and in anyone with hypertension. It's a vasoconstrictor that may reduce uterine blood flow. Older…

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