Adapalene

Active · CAS 106685-40-9

Avoid

Avoid adapalene (Differin) during pregnancy. Although it’s a newer, third-generation retinoid with limited human pregnancy data, the class-wide retinoid teratogenicity caution applies.…

DMDM Hydantoin

Preservative · CAS 6440-58-0

Avoid

Avoid DMDM hydantoin in pregnancy. It’s a formaldehyde-releasing preservative that slowly emits formaldehyde over the product’s shelf life — exposure source is…

Formaldehyde

Preservative · CAS 50-00-0

Avoid

Avoid formaldehyde during pregnancy. IARC Group 1 human carcinogen. Inhalation and dermal exposure are linked to increased miscarriage risk in salon-worker studies…

Hydroquinone

Active · CAS 123-31-9

Avoid

Avoid hydroquinone during pregnancy. Up to 35–45% systemic absorption — the highest of any topical cosmetic ingredient. Pregnancy data are limited, so…

Ibuprofen

Active · CAS 15687-27-1

Avoid

Avoid ibuprofen after 20 weeks of pregnancy. NSAIDs can cause fetal kidney problems, oligohydramnios, and (after 30 weeks) premature closure of the…

Isotretinoin

Active · CAS 4759-48-2

Avoid

Absolutely avoid isotretinoin (Accutane) in pregnancy. It is one of the most potent known human teratogens — first-trimester exposure causes a roughly…

Octinoxate

Uv filter · CAS 5466-77-3

Avoid

Avoid octinoxate during pregnancy. The most-used chemical UVB filter globally, with estrogenic endocrine-disruptor signals in animal and cell studies. Flagged alongside oxybenzone…

Oxybenzone

Uv filter · CAS 131-57-7

Avoid

Avoid oxybenzone during pregnancy. Endocrine disruptor that crosses the placenta. Studies link higher maternal urinary oxybenzone to altered birth weight and Hirschsprung…

Phthalates

Plasticizer · CAS 117-81-7

Avoid

Avoid phthalates during pregnancy. This family of endocrine-disrupting plasticizers is associated with altered male reproductive development (reduced anogenital distance) and neurodevelopmental effects…

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